BPC 157/TB500 20mg

BPC-157 + TB500 is a peptide research blend consisting of two extensively studied investigational peptides: BPC-157 (Body Protection Compound-157) and TB500 (a synthetic peptide fragment derived from Thymosin Beta-4).

BPC-157 is a synthetic pentadecapeptide composed of 15 amino acids and modeled after a peptide sequence associated with proteins found in gastric tissue. TB500 is a laboratory-produced peptide derived from the naturally occurring Thymosin Beta-4 protein, which is involved in cellular migration, cytoskeletal organization, and tissue-response pathways.

Researchers have investigated these peptides individually and in combination for their potential interactions with biological processes involved in cellular signaling, tissue remodeling, vascular response, angiogenesis-related pathways, connective tissue biology, and inflammatory signaling mechanisms.

Scientific interest in this peptide combination stems from the complementary biological pathways associated with each peptide in preclinical and experimental research settings.

Mechanism Overview

BPC-157 has been investigated for potential interactions with:

• Nitric oxide signaling pathways

• VEGF-related angiogenesis

• Endothelial function

• Fibroblast activity

• Extracellular matrix remodeling

• Cellular signaling involved in tissue-response mechanisms

TB500 has been investigated for potential interactions with:

• Actin regulation and cytoskeletal organization

• Cellular migration pathways

• Tissue remodeling processes

• Angiogenesis-related mechanisms

• Cellular differentiation pathways

• Inflammatory signaling pathways

These mechanisms remain investigational and are primarily based on preclinical and laboratory research.

Structure

BPC-157

• Sequence: GEPPPGKPADDAGLV

• CAS: 1375250-19-6

• Molecular Weight: ~1419.5 g/mol

TB500 (Thymosin Beta-4 Fragment)

• Sequence: LKKTETQ

• CAS: Varies by manufacturer and peptide fragment specification

• Synthetic peptide fragment derived from Thymosin Beta-4

Quality

Quality testing is an integral part of evaluating peptides, as purity alone does not provide a complete picture of product quality.

A comprehensive quality review should include:

• HPLC purity testing to assess related impurities

• LC-MS or LC-MS/MS testing to confirm molecular identity

• Peptide content (assay) testing to verify labeled quantity

• Residual solvent analysis when applicable

• Endotoxin screening and contaminant testing

Each batch is supported by a lot-specific Certificate of Analysis (COA) detailing test methods, results, testing dates, and laboratory information.

Evidence Status

Current evidence for both BPC-157 and TB500 is primarily preclinical. Neither peptide has an FDA-approved therapeutic indication.

References

Sikiric, P., et al. (2020). Stable gastric pentadecapeptide BPC 157, Robert's stomach cytoprotection, and adaptive cytoprotection. Current Pharmaceutical Design, 26(24), 2671–2695.

Seiwerth, S., et al. (2014). BPC 157 and blood vessels. Current Pharmaceutical Design, 20(7), 1121–1125.

He, L., et al. (2022). Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157 in rats and dogs. Frontiers in Pharmacology, 13, 1026182.

Chang, C. H., et al. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of Applied Physiology, 110(3), 774–780.

Goldstein, A. L., & Kleinman, H. K. (2015). Advances in the basic and clinical applications of thymosin beta 4. Expert Opinion on Biological Therapy, 15(S1), S139-S145.

Malinda, K. M., et al. (1999). Thymosin beta 4 accelerates wound healing. Journal of Investigative Dermatology, 113(3), 364–368.

Research Use Only

All products on this site are intended for research and development use only.

Products are not for human consumption of any kind. The statements made on this website have not been evaluated by the U.S. Food and Drug Administration. The products offered by this company are not intended to diagnose, treat, cure, or prevent any disease.

All products are sold strictly for research, laboratory, analytical, or educational purposes only and are not intended for human consumption, veterinary use, or clinical application.