SEMAX

Overview:

Semax is a synthetic peptide analog derived from a fragment of adrenocorticotropic hormone (ACTH), commonly described as ACTH(4-7) linked to the Pro-Gly-Pro sequence. It is typically represented by the sequence Met-Glu-His-Phe-Pro-Gly-Pro.

Scientific interest around Semax has centered on neurochemical, neurotrophic, and stress-response models. It has been studied in experimental and clinical research settings, particularly in Russian literature, for potential interactions with neurotrophic factor expression, melanocortin-related pathways, and central nervous system signaling.

Semax should be discussed as a synthetic ACTH-fragment-derived research peptide. Mechanistic findings from preclinical or region-specific clinical literature should be separated from broad claims about cognition, mood, performance, or disease outcomes.

Mechanism Overview:

Semax has been investigated for potential interactions with melanocortin-related signaling, neurotrophic factor expression, monoaminergic signaling, and neuroinflammatory models. Research has discussed effects on brain-derived neurotrophic factor and other CNS-related pathways, but these mechanisms remain context-dependent and should not be interpreted as established clinical outcomes outside approved or region-specific medical use.

Structure:

·       Sequence: Met-Glu-His-Phe-Pro-Gly-Pro 

·       CAS: 80714-61-0

·       Molecular Weight: ~813.9 g/mol