TB-500

Overview:

TB-500 is a synthetic peptide fragment associated with thymosin beta-4, a naturally occurring 43-amino-acid peptide involved in actin regulation and cellular movement. TB-500 is commonly identified as the N-acetylated 17–23 fragment of thymosin beta-4, with the sequence Ac-LKKTETQ. It has been studied primarily in laboratory, analytical, animal, and preclinical research contexts.

Scientific interest around TB-500 comes from its relationship to thymosin beta-4 biology, particularly processes involving actin binding, cell migration, angiogenesis-related signaling, and tissue-remodeling models. Because thymosin beta-4 is associated with cytoskeletal organization and cellular movement, TB-500 is often discussed in the context of experimental models involving structural remodeling and wound-response pathways.

Mechanism Overview:

TB-500 has been investigated for potential relevance to thymosin beta-4-associated pathways, including actin regulation, cell migration, endothelial activity, angiogenesis-related signaling, and extracellular matrix remodeling. The actin-binding region of thymosin beta-4 has been studied for its role in cell movement and vascular-response models, while TB-500 and its metabolites have been evaluated in analytical and wound-healing assay research. These mechanisms are primarily based on laboratory and preclinical research and are not equivalent to established clinical outcomes.

Structure:

Sequence: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln 
CAS: 885340-08-9
Molecular Weight: ~889.0 g/mol